The ChitoLytic Vegetal Mushroom Chitosan Oligosaccharide is produced from the cell walls of mushrooms, specifically from the Agaricus bisporus species. It’s a high-quality grade oligomer of chitosan. Unlike, chitosan its highly water-soluble without the need for acidic conversion.
This mushroom, fungal, non-animal, plant-based chitosan oligosaccharide forms gels with multivalent anions and clear solutions that dry to strong, clear films. It’s ideal for scaffolds, cell therapy, drug delivery, and biomedical applications. It’s a natural biopolymer that’s biocompatible, biodegradable, antibacterial, an adhesive to tissue, and can be used in a variety of applications, e.g.,
Chitosan oligosaccharide is known for its variety of characteristics and functionalities as a biopolymer and more specifically as a biomaterial due to biological activities such as anti-tumor, anti-inflammatory, antioxidant, antibacterial activity, biological recognition, and immune-enhancing effects, etc. This has attracted research interest from various application areas such as drugs, medical devices, food, cosmetics, tissue engineering, and agriculture, to name a few.
Chitosan oligosaccharide (COS) is an oligomer of chitosan with a low average molecular weight (MW) < 5,000 Da. Its chemical structure, like chitosan, is a linear binary copolymer consisting of β-1, 4-linked 2-acetamido-2-deoxy-β-D-glucopyranose (GlcNAc) and 2-amino-2-deoxy-β-D-glucopyranose (GlcN). The interest in Chitosan oligosaccharide use is not only due to its physical-chemical properties such as better water solubility and being cationic at neutral pH, but also from its biological activities, e.g., anti-tumor, anti-inflammatory, anti-oxidant, anti-bacterial activity, biological recognition, and immune-enhancing effects. These unique properties and activities continuously attract research interests in drugs, food, cosmetics, biomaterials, and tissue engineering fields.
An oligosaccharide, a sugar, is a saccharide polymer containing a small number monosaccharides (simple sugars). An oligosaccharide commonly refers to a carbohydrate polymer whose molecules are composed of a relatively small number of monosaccharide units. The parameters for an oligosaccharide vary, however they are typically counted as any sugar with between 3 and 9 monosaccharide units. Oligosaccharides are formed when two or more monosaccharides join together by O-glycosidic bonds. Examples include sucrose, lactose and maltose. Specific enzymes are used to catalyze the glycosidic bonds in oligosaccharides and each sugar must be specific to each enzyme used for each new glycosidic bond.
Carbohydr Polym 2021 Aug 15;266:118100
Moist, breathable, and antibacterial microenvironment can promote cell proliferation and migration, which is beneficial to wound healing. Here, we fabricated a novel sodium alginate-chitosan oligosaccharide zinc oxide (SA-COS-ZnO) composite hydrogel by spontaneous Schiff base reaction, using aldehydated sodium alginate (SA), chitosan oligosaccharide (COS), and zinc oxide (ZnO) nanoparticles, which can provide a moist and antibacterial environment for wound healing.
Poult Sci 2020 Oct;99(10):4824-4831
The results suggested that COS could be used as an effective feed additive to maintain growth performance, liver function, meat quality, muscle glycolytic metabolism, and oxidative status of yellow-feather broilers under heat stress. The improved meat quality is possibly through reducing muscle glycolysis metabolism and improving muscle oxidative status by dietary COS supplementation in broilers under heat stress.
Mol Plant Microbe Interact. 2018 Dec;31(12):1271-1279
Chitosan oligosaccharide (COS) is an effective plant immunity elicitor; however, its induction mechanism in plants is complex and needs further investigation. In this study, the Arabidopsis–Pseudomonas syringae pv. tomato DC3000 (hereafter called DC3000) interaction was used to investigate the induction effect and the underlying mechanisms of COS.